Berberine (BBR) is alkaloid that belongs to isoquinoline group and it has a molecular formulation of C20H18NO4. BBR can be extracted from many plant people, which includes AnnonaceaeBerberine is really a quaternary ammonium salt in the protoberberine team of isoquinoline alkaloids(Caliceti et al., 2016). The latter are present from the roots, bark
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